Pei-Yu Chen is a Research Scientist at Yale Cardiovascular Research Center, under the guidance of Prof. Michael Simons. Chen’s research centers on the mechanisms of vascular dysfunction, with emphasis on clinical relevance and translational research. Her current research focuses on understating how transforming growth factor beta (TGFb) signaling controlling vascular cell fate. She made significant contribution to understanding the paradoxical role of TGFb signaling and inflammation in vascular disease. She provided the first evidence that endothelial cell to mesenchymal transition (EndMT) contributes to human diseases including transplant rejection and atherosclerosis. This laid the foundation for a series of studies that examined EndMT’s role in cardiovascular biology and publications in Cell Reports, Science Signaling, JCI, and EMBO Mol Med among others. Chen received her B.S. from Kaohsiung Medical University. She received her Ph.D in Molecular Genetics and Cell Biology from University of Maine.