Selected Literature
Publications
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Pei-Yu Chen, et.al., Nature Metabolism, 2019
Transforming endothelial cells in atherosclerosis. Howe KL and Fish, JE. Nature Metabolism, 2019
Yale-led study offers promising approach to reducing plaque in arteries August 26, 2019
Endothelial-to-mesenchymal transition drives atherosclerosis progression Pei-Yu Chen, Lingfeng Qin, Nicolas Baeyens, Guangxin Li, Titilayo Afolabi, Madhusudhan Budatha, George Tellides, Martin A. Schwartz, and Michael Simons, J. Clin Invest. 2015;125(12):4514-4528
Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis. Chen PY, Simons M. Curr Opin Lipidol. 2018 Oct;29(5):397-403. https://www.ncbi.nlm.nih.gov/pubmed/30080704
Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition. Chen PY, Simons M. Curr Drug Targets. 2016;17(15):1707-1713. Review. https://www.ncbi.nlm.nih.gov/pubmed/27138761
FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. Cell Rep. 2012 Dec 27;2(6):1684-96. https://www.ncbi.nlm.nih.gov/pubmed/23200853
Bmpr1a and Its Role in EndoMT in Pulmonary Arterial Hypertension. Lee, HW., Adachi,Park, S., Kowalski, P., Anderson, D., Simons, M., Jin, SW., Chun, H.J. CirculationVol. 138, No. Suppl_1 Abstract 17070 https://www.ahajournals.org/doi/abs/10.1161/circ.138.suppl_1.17070
Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles. Khan OF, Kowalski PS, Doloff JC, Tsosie JK, Bakthavatchalu V, Winn CB, Haupt J, Jamiel M, Langer R, Anderson DG. Sci Adv. 2018 Jun 27;4(6) https://www.ncbi.nlm.nih.gov/pubmed/29963629
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Dahlman JE, Kauffman KJ, Xing Y, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2060-2065. https://www.ncbi.nlm.nih.gov/pubmed/28167778
Small RNA combination therapy for lung cancer. Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T. Proc Natl Acad Sci U S A.2014 Aug 26;111(34) https://www.ncbi.nlm.nih.gov/pubmed/25114235
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. Nat Nanotechnol. 2014 Aug;9(8):648-655. https://www.ncbi.nlm.nih.gov/pubmed/24813696